mir۱۷hg gene polymorphism and the risk of recurrent spontaneous abortion
نویسندگان
چکیده
materials and methods the case and control groups were studied for the association between polymorphism of mir17hg and recurrent pregnancy loss in iranian females. one-hundred patients with recurrent abortions (at least two) as cases and one-hundred healthy female with two or more normal term deliveries and without a history of abortion were selected as controls. total genomic dna was isolated from blood leukocytes. snps were studied with alu1 as a restriction enzyme. results results of the present study indicated significant association between rs6492538 polymorphism and recurrent pregnancy loss (p > 0.05). conclusions the results of the present study provide evidence for association between genetic variation in mir17hg and recurrent spontaneous abortion. further studies will be required to validate the significance of the studied genetic variation in diverse populations and its regulatory role on target genes. background recurrent pregnancy loss (rpl) is two or more consecutive pregnancy losses before 20 weeks of gestation. so far the disease is known for a variety of reasons, but still about 50% of recurrent pregnancy losses are unknown. the mirnas are a family of 20 - 25 nucleotide rna that inhibit translation of the target gene or mrna degradation and play a key role in a variety of regulatory pathways. the mirna is involved in embryonic developments and regulatory disorders which cause numerous diseases including heart diseases and pregnancy-associated disorders. recent studies suggest that common genetic factors may exist between ischemic heart disease and abortion. objectives the current study aimed to investigate the relationship between rs6492538 polymorphism of mir17hg gene and recurrent spontaneous abortion, which might be clinically useful as a marker to assess risks for recurrent pregnancy loss to provide good health care during pregnancy.
منابع مشابه
Evaluation of the Association between the C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene and Recurrent Spontaneous Abortion
Introduction: One factor known to cause thrombophilia in women with unexplained recurrent spontaneous abortion (RSA) is C677T polymorphism of methylenetetrahydrofolate reductase gene. This study aimed to determine the association between RSA and MTHFR C677T polymorphism in Iranian patients. Methods: In this case-control study, 30 patients with previous history of two or more consecutive unexpla...
متن کاملAssociation between the A1298C Polymorphism of the Methylenetetrahydrofolate Reductase Gene and Recurrent Spontaneous Abortion
Introduction: A factor known to cause thrombophilia in women with recurrent pregnancy loss (RPL) is the A1298C polymorphism of methylenetetrahydrofolate reductase gene (MTHFR). This study aimed to determine the association between RPL and this polymorphism in Iranian patients. Methods: In this case-control study, 30 patients with a previous history of two or more consecutive unexplained abortio...
متن کاملAssociation between HOXA10 (rs267601473) polymorphism and recurrent spontaneous abortion
Introduction: Recurrent spontaneous abortion is defined as the occurrence of more than two clinical miscarriages in one woman. Several factors, including endocrine irregularities, genetics and environmental factors, are involved in this kind of infertility.The aim of this study was to survey the association of HOXA10 (rs267601473) polymorphism with the risk of recurrent spontaneous abortion in ...
متن کاملAnti-Thyroid Peroxidase and Risk of Recurrent Spontaneous Abortion
Background Approximately 2-4% of all women have recurrent spontaneous abortion (RSA); however, the cause is determined in only 50% of cases. Recent studies have shown an association between thyroid autoantibodies as a sign of thyroid autoimmunity and abortion. The aim of the present study was to determine whether circulating anti-thyroid peroxidase (anti-TPO) was associated with RSA. MaterialsA...
متن کاملthe study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region
چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اول[Progesterone receptor gene polymorphism and recurrent spontaneous abortion].
PURPOSE To assess a possible association between polymorphism of the progesterone receptor gene (PROGINS) and recurrent spontaneous abortion (RSA). METHODS In this case-control study, 85 women with at least three previous spontaneous abortions without an identifiable cause (RSA Group) and 157 women with at least two previous term pregnancies without pathologies and no previous miscarriage (Co...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
gene, cell and tissueجلد ۳، شماره ۱، صفحات ۰-۰
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023